Blog

Video » Unearthing Secrets of New Neurons

http://www.nimh.nih.gov/news/media/2014/unearthing-secrets-of-new-neurons.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

Unearthing Secrets of New Neurons
NIMH | Recent Updates

Concept Clearance » Methodologies to Enhance Understanding of HIV-Associated Social Determinants

http://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2014/methodologies-to-enhance-understanding-of-hiv-associated-social-determinants.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

This initiative aims to support formative work and methodological innovations to build effective interventions that will address or mitigate the impact of social determinants that drive negative HIV-related outcomes. Mechanisms that may underlie these social determinants include factors at individual, social, and cultural levels.
NIMH | Recent Updates

Concept Clearance » Monitoring Antiretroviral Adherence to Improve HIV Treatment and Prevention

http://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2014/monitoring-antiretroviral-adherence-to-improve-hiv-treatment-and-prevention.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

The aims of this initiative are to improve treatment for HIV/AIDS and HIV prevention by advancing: (i) Methods for real-time or prospective monitoring of oral ARV adherence (antiretroviral therapy [ART], pre-exposure prophylaxis [PrEP]); (ii) Timely and targeted delivery of interventions when adherence monitoring reveals deficits; and, (iii) Predictive models that estimate current risk of viral breakthrough or HIV infection for a given individual based on ART adherence monitoring and related data.
NIMH | Recent Updates

Concept Clearance » Exosomes and HIV Neuropathogenesis

http://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2014/exosomes-and-hiv-neuropathogenesis.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

The goal of this initiative is to stimulate further research on the central role of exosomes in HIV-associated neurocognitive disorders (HAND). Specifically, this initiative encourages studies addressing the contribution of exosomes in modulating chronic inflammation in HAND, in addition to studies exploring the potential use of exosomes in the delivery of central nervous system (CNS)-targeted therapeutics.
NIMH | Recent Updates

Concept Clearance » Improving Mental Health of Populations with Access to Cutting-edge Technologies (IMPACT)

http://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2014/improving-mental-health-of-populations-with-access-to-cutting-edge-technologies-impact.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

This initiative aims to support the research, development, and testing of technology-based solutions focused on the diagnosis and treatment of mental illness.
NIMH | Recent Updates

Concept Clearance » For a More Targeted and Safer Use of Antipsychotics in Youth

http://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2014/for-a-more-targeted-and-safer-use-of-antipsychotics-in-youth.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

The goal of this initiative is to develop and test for effectiveness a treatment algorithm to manage severe mood and behavior dysregulation in non-psychotic children and adolescents for whom antipsychotics are commonly prescribed in the community.
NIMH | Recent Updates

Concept Clearance » Novel Assays to Address Translational Gaps in Treatment Development

http://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2014/novel-assays-to-address-translational-gaps-in-treatment-development.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

This initiative addresses a translational gap in therapeutic discovery and development that exists between the preclinical screening pipeline and early experimental medicine studies in humans. Support would be provided for collaborative teams focused on developing, evaluating, and optimizing clinically meaningful and biologically-based measures that tap into functional domains to inform therapeutic development. Studies would evaluate the alignment or divergence of measures across preclinical screening and into healthy humans. Ideally, the initiative would illuminate the types of preclinical data and approaches that may be useful (or not useful) in predicting effects in humans based on biological conservation of signaling pathways and circuits, and provide tools needed to test novel therapeutic targets or mechanisms in animals and in humans.
NIMH | Recent Updates

Science News » Common Gene Variants Account for Most Genetic Risk for Autism

http://www.nimh.nih.gov/news/science-news/2014/common-gene-variants-account-for-most-genetic-risk-for-autism.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

Most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches.
NIMH | Recent Updates

Science News » Schizophrenia’s Genetic “Skyline” Rising

http://www.nimh.nih.gov/news/science-news/2014/schizophrenias-genetic-skyline-rising.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

The largest genomic dragnet of any psychiatric disorder to date has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported.
NIMH | Recent Updates

Blog Post » Mapping the Risk Architecture of Mental Disorders

http://www.nimh.nih.gov/about/director/2014/mapping-the-risk-architecture-of-mental-disorders.shtml?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary

In this blog, Dr. Insel describes the results of two new genetics studies and why they are milestones in our understanding of the genetics of autism and schizophrenia.
NIMH | Recent Updates